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Cannabidiol - Wikipedia Cannabidiol has low affinity for the cannabinoid CB 1 and CB 2 receptors, although it can act as an antagonist of CB 1 /CB 2 agonists despite this low affinity. Cannabidiol may be an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.
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